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$825 million in aggregate milestone payments: in total, Pharmacyclics is entitled to $825 million in milestone payments tied to various clinical, regulatory, and commercial milestones. And with over $560 million in net cash, it is highly unlikely that Pharmacyclics will have a need to raise new capital, given that it is expected to be profitable in both 2013 and 2014, albeit primarily through milestone payments as Imbruvica sales ramp higher. Pharmacyclics is moving towards sustainable profitability, the "easy" money in the stock has been made, and although we see meaningful value remaining in Pharmacyclics from a long term perspective, gains will not come overnight Investors must contend with a new slate of concerns..